Hypertrophic Cardiomyopathy in a Patient with Subaortic Membrane
Abstract
Left ventricular outflow tract obstruction is a presentation of subaortic membrane. Asymmetric septal hypertrophy is an uncommon echocardiographic finding in this condition. Nonetheless, it is a common presentation of hypertrophic cardiomyopathy. These 2 conditions can coexist in the same patient. We describe a woman with a significant obstructive subaortic membrane and asymmetric septal hypertrophy, with a final diagnosis of hypertrophic cardiomyopathy confirmed by cardiac magnetic resonance imaging.
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2. Singh A, Razzouk L, Massera D, Sherrid MV. Acute Left Ventricular Ballooning: Tools to Differentiate Hypertrophic Cardiomyopathy with Outflow Obstruction from Neurohumoral Takotsubo Syndrome. Rev Cardiovasc Med. 2023 May 19;24(5):154.
3. Guigui SA, Torres C, Escolar E, Mihos CG. Systolic anterior motion of the mitral valve in hypertrophic cardiomyopathy: a narrative review. J Thorac Dis. 2022 Jun;14(6):2309-25.
4. Stankowski K, Celeste F, Muratori M, Cannata F, Cosentino N, Fazzari F, et al. Exploring Morphologic and Functional Variants in Hypertrophic Cardiomyopathy: An Echocardiographic and Doppler Review. Diagnostics (Basel). 2025 Oct 24;15(21):2688.
5. Kubo T, Maekawa Y, Hongo K, Yamamoto S, Izumiya Y, Yamakawa H, et al. Cardiac characteristics of Fabry disease from baseline enrolment data in a nationwide prospective Japanese registry. Int J Cardiol. 2026 Feb 15;445:134071.
6. Khan AA, Tang GHL, Engstrom K, Khan M, Patel N, Dangas GD, et al. Aortic stenosis with severe asymmetric septal hypertrophy: a novel management strategy to improve TAVR outcomes. JACC Cardiovasc Interv. 2019 Nov 11;12(21):2228-30.
7. Kannappan M, Maron BJ, Rastegar H, Pandian NG, Maron MS, Rowin EJ. Underappreciated occurrence of discrete subaortic membranes producing left ventricular outflow obstruction in hypertrophic cardiomyopathy. Echocardiography. 2017 Aug;34(8):1247-9.
8. Anderson MJ, Arruda-Olson A, Gersh B, Geske J. Subaortic membrane mimicking hypertrophic cardiomyopathy. BMJ Case Rep. 2015 Nov 4;2015:bcr2015212321.
9. Qureshi A, Awuor S, Martinez M. Adult presentation of subaortic stenosis: another great hypertrophic cardiomyopathy mimic. Heart Lung Circ. 2015 Jan;24(1):e7-e10.
10. Camilli M, Meucci MC, Del Buono MG, Ierardi C, Delogu AB, Crea F. Hypertrophic cardiomyopathy and membranous subaortic stenosis: a rare, but possible association. J Cardiovasc Med (Hagerstown). 2020 Feb;21(2):164-7.
11. Ayoub C, Brieger D, Chard R, Yiannikas J. Fixed left ventricular outflow tract obstruction mimicking hypertrophic obstructive cardiomyopathy: pitfalls in diagnosis. Echocardiography. 2016 Nov;33(11):1753-61.
12. Mehra N, Ali AH, Desai MY. Obstructive hypertrophic cardiomyopathy: a review of new therapies. Future Cardiol. 2023 Oct;19(13):661-70.
2. Singh A, Razzouk L, Massera D, Sherrid MV. Acute Left Ventricular Ballooning: Tools to Differentiate Hypertrophic Cardiomyopathy with Outflow Obstruction from Neurohumoral Takotsubo Syndrome. Rev Cardiovasc Med. 2023 May 19;24(5):154.
3. Guigui SA, Torres C, Escolar E, Mihos CG. Systolic anterior motion of the mitral valve in hypertrophic cardiomyopathy: a narrative review. J Thorac Dis. 2022 Jun;14(6):2309-25.
4. Stankowski K, Celeste F, Muratori M, Cannata F, Cosentino N, Fazzari F, et al. Exploring Morphologic and Functional Variants in Hypertrophic Cardiomyopathy: An Echocardiographic and Doppler Review. Diagnostics (Basel). 2025 Oct 24;15(21):2688.
5. Kubo T, Maekawa Y, Hongo K, Yamamoto S, Izumiya Y, Yamakawa H, et al. Cardiac characteristics of Fabry disease from baseline enrolment data in a nationwide prospective Japanese registry. Int J Cardiol. 2026 Feb 15;445:134071.
6. Khan AA, Tang GHL, Engstrom K, Khan M, Patel N, Dangas GD, et al. Aortic stenosis with severe asymmetric septal hypertrophy: a novel management strategy to improve TAVR outcomes. JACC Cardiovasc Interv. 2019 Nov 11;12(21):2228-30.
7. Kannappan M, Maron BJ, Rastegar H, Pandian NG, Maron MS, Rowin EJ. Underappreciated occurrence of discrete subaortic membranes producing left ventricular outflow obstruction in hypertrophic cardiomyopathy. Echocardiography. 2017 Aug;34(8):1247-9.
8. Anderson MJ, Arruda-Olson A, Gersh B, Geske J. Subaortic membrane mimicking hypertrophic cardiomyopathy. BMJ Case Rep. 2015 Nov 4;2015:bcr2015212321.
9. Qureshi A, Awuor S, Martinez M. Adult presentation of subaortic stenosis: another great hypertrophic cardiomyopathy mimic. Heart Lung Circ. 2015 Jan;24(1):e7-e10.
10. Camilli M, Meucci MC, Del Buono MG, Ierardi C, Delogu AB, Crea F. Hypertrophic cardiomyopathy and membranous subaortic stenosis: a rare, but possible association. J Cardiovasc Med (Hagerstown). 2020 Feb;21(2):164-7.
11. Ayoub C, Brieger D, Chard R, Yiannikas J. Fixed left ventricular outflow tract obstruction mimicking hypertrophic obstructive cardiomyopathy: pitfalls in diagnosis. Echocardiography. 2016 Nov;33(11):1753-61.
12. Mehra N, Ali AH, Desai MY. Obstructive hypertrophic cardiomyopathy: a review of new therapies. Future Cardiol. 2023 Oct;19(13):661-70.
| Files | ||
| Issue | Vol 21 No 3 (2026) | |
| Section | Case Report(s) | |
| DOI | https://doi.org/10.18502/rhythm.v21i3.22568 | |
| Keywords | ||
| Hypertrophic Cardiomyopathy Subaortic Membrane Echocardiography Cardiac Magnetic Resonance Imaging (CMR) | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Ghaderian H, Asl-Fallah S, Mansourian S, Hosseinsabet A. Hypertrophic Cardiomyopathy in a Patient with Subaortic Membrane. Res Heart Yield Transl Med. 2026;21(3):249-252.
