Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 4 4 2009 10 19 244 247 Mohammad Yousef Aarabi Moghaddam Shaheed Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehr Hojatollah Mortezaian Shaheed Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehr Seyed Reza Miri Shaheed Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehr 2015 10 03 Cornelia de Lange syndrome (CdLS) is a rare syndrome characterized by multiple congenital anomalies, mental retardation, characteristic facial appearance, developmental delay, skeletal malformation, hirsutism, and various cardiac and ophthalmological problems. The diagnosis of this syndrome is clinical. The patient of the present case report was the second case of CdLS from Iran; only a few cases of CdLS have thus far been reported from countries outside Europe and North America. Reporting CdLS cases of different ethnic backgrounds can add nuances to the phenotypic description of the syndrome and be helpful in diagnosis. Furthermore, an increased awareness of this syndrome may result in an early diagnosis and a decrease in morbidity. https://rhythm.tums.ac.ir/index.php/jthc/article/view/151 https://rhythm.tums.ac.ir/index.php/jthc/article/download/151/149