Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 5 2 2010 04 15 92 94 Rezayat Parvizi Cardiovascular Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran. Rasoul Ibrahim Abdulrahman Cardiovascular Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran. Rezvaneh Salehi Cardiovascular Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran. Ghader Shah Mohamadi Cardiovascular Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran. 2015 10 03 Splenomegaly-induced thrombocytopenia is fully described in hematological and surgical literature, but its association with severe aortic stenosis is rare. We present a case of severe aortic valve stenosis with severe splenomegaly-induced thrombocytopenia in which aortic valve replacement was done with a number 23 homograft and splenectomy was performed after the end of cardiopulmonary bypass. Platelet count turned to normal value post-operatively, and the patient spent an ordinary convalescence period and was discharged from the hospital without any complications. https://rhythm.tums.ac.ir/index.php/jthc/article/view/169 https://rhythm.tums.ac.ir/index.php/jthc/article/download/169/167