Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 5 3 2010 09 15 116 121 Pier Mannucci Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Università degli Studi di Milano, Milan, Italy Luca Lotta Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Università degli Studi di Milano, Milan, Italy Flora Peyvandi Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Università degli Studi di Milano, Milan, Italy 2015 10 03 Myocardial infarction (MI) and its major determinant, coronary artery disease (CAD), are complex diseases arising from the interaction between several genetic and environmental factors. Until recently, the genetic basis of these diseases was poorly understood. Genome-wide genetic association studies have afforded a comprehensive insight into the association between genetic variants and diseases. To date, seven genome-wide association studies have been conducted in CAD/MI, identifying thirteen genomic regions at which common genetic variants influence the predisposition to these diseases. This review article summarizes the progress achieved in the genetic basis of MI and CAD by means of genome-wide association studies and the potential clinical applications of these findings. https://rhythm.tums.ac.ir/index.php/jthc/article/view/173 https://rhythm.tums.ac.ir/index.php/jthc/article/download/173/171