Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 6 1 2011 03 15 37 40 Mohammad Hossein Davari Birjand Cardiovascular Research Center, Birjand University of Medical Sciences, Birjand, Iran. Toba Kazemi Birjand Cardiovascular Research Center, Birjand University of Medical Sciences, Birjand, Iran. Hossein Alimirzaei Vali Asr Hospital, Birjand University of Medical Sciences, Birjand, Iran. Mohamad Reza Rezvani Birjand Cardiovascular Research Center, Birjand University of Medical Sciences, Birjand, Iran. 2015 10 03 Marfan’s syndrome (MFS) is a genetic disorder associated with autosomal dominant inheritance. In MFS, the most prevalent cause of death is cardiovascular involvement. Here we introduce a family with a severe penetration of MFS. Eleven members of this family have MFS (father, two daughters, three sons, and five grandchildren). The most common cardiac involvement in our patients was mitral valve prolapse as manifested by mitral regurgitation. At ten years’ follow-up, two patients had aortic root dilatation running the risk of aortic dissection; they were, therefore, scheduled for cardiac surgery, during which the Bental procedure was successfully performed. Fortunately, all of the members of this family are currently alive. https://rhythm.tums.ac.ir/index.php/jthc/article/view/198 https://rhythm.tums.ac.ir/index.php/jthc/article/download/198/196