Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 20 2 2025 10 07 167 169 Ali Bozorgi Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. 2025 10 07 The European Society of Cardiology Congress (ESC) 2025 in Madrid delivered a concentrated set of clinical trials with immediate relevance to practice across cardiology subspecialties. While the congress spanned topics from hypertension and coronary disease to cardiomyopathies and device therapy, a subset of trials is especially salient for electrophysiologists: comparative outcomes of pulsed-field vs radiofrequency ablation in atrial fibrillation (AF); strategies for anticoagulation after successful AF ablation; and broader therapeutic advances (oral myosin inhibitors for obstructive hypertrophic cardiomyopathy [HCM]) that shift paradigms in medical management. Here, I summarize these trial findings, discuss their electrophysiology implications, and propose priorities for future research and guideline consideration. https://rhythm.tums.ac.ir/index.php/jthc/article/view/2373 https://rhythm.tums.ac.ir/index.php/jthc/article/download/2373/1222