Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 7 3 2015 10 11 121 127 EN Fardin Yousefshahi Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Khosro Barkhordari Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Ali Movafegh Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Vida Tavakoli Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Omalbanin Paknejad Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Payvand Bina Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Hadi Yousefshahi Rajaee Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Mahmood Sheikh-Fathollahi Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 10 2015 10 10 Background: Extubation is associated with the risk of complications such as accumulated secretion above the endotracheal tube cuff, eventual atelectasia following a reduction in pulmonary volumes because of a lack of physiological positive end expiratory pressure, and intra-tracheal suction. In order to reduce these complications, and, based on basic physiological principles, a new practical extubation method is presented in this article. Methods: The study was designed as a six-month prospective cross-sectional clinical trial. Two hundred fifty-seven patients undergoing coronary artery bypass grafting (CABG) were divided into two groups based on their scheduled surgery time. The first group underwent the conventional extubation method, while the other group was extubated according to a new described method. Arterial blood gas (ABG) analysis results before and after extubation were compared between the two groups to find the effect of the extubation method on the ABG parameters and the oxygenation profile. Results: In all time intervals, the  partial pressure of oxygen in arterial blood / fraction of inspired oxygen(PaO/ FiO ) ratio in the new method group patients was improved compared to that in the conventional method; some differences, like PaO\FiO four hours after extubation, were statistically significant, however (p value = 0.0063). Conclusion:  The  new  extubation  method  improved somerespiratory  parameters  and  thus  attenuated  oxygenationcomplications and amplified oxygenation after extubation.   https://rhythm.tums.ac.ir/index.php/jthc/article/view/259 https://rhythm.tums.ac.ir/index.php/jthc/article/download/259/253