Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 8 4 2015 10 11 202 204 EN Feridoun Sabzi Cardiovascular Medical Center of Imam Ali Hospital, Kermanshah, Iran. Babak Nasiri Cardiovascular Medical Center of Imam Ali Hospital, Kermanshah, Iran. 2015 10 11 2015 10 11 Myxomas are the most common benign cardiac tumors. Myxomas are more common in the left heart chamber than the right side chamber. An extracardiac origin presenting as a right atrial mass is very rare. We present a case of myxoma originating in the superior vena cava (SVC) in a 24-year-old man, who underwent surgical resection. Preoperative two-dimensional echocardiography demonstrated a mass in the right atrium. Intraoperatively, the tumor was found to have originated from the SVC orifice. The tumor was excised from the SVC by opening the one-third proximal portion of the SVC. Pathological examination revealed a myxoma, and one-year follow-up showed no evidence of the recurrence of any tumors in the SVC. https://rhythm.tums.ac.ir/index.php/jthc/article/view/311 https://rhythm.tums.ac.ir/index.php/jthc/article/download/311/304