Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 9 1 2015 10 11 1 8 EN Reza Karbasi-Afshar Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran AND Department of Cardiology, Baqiyatallah University of Medical Sciences, Tehran, Iran. Amin Saburi Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Hossein Khedmat Baqiyatallah Research Center for Gastroenterology and Liver Disease, Tehran, Iran. 2015 10 11 2015 10 11 Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in the United States and other industrialized countries, and the reported prevalence in the developing countries is also rather high. This disease is associated with a high rate of morbidity and mortality and damage to the other organs. The cardiovascular system is, perhaps, the most vulnerable organ to NAFLD adverse effects to the extent that most mortality associated with this disease is reportedly from the cardiovascular system rather than from the liver itself. In this article, we review the significant aspects of cardiovascular disorders associated with NAFLD, including the epidemiology of cardiovascular diseases in NAFLD patients, factors that interfere in this relationship like hypertension, severity of NAFLD, and age of the patients, and finally preventive strategies whose employment could significantly improve the outcome. https://rhythm.tums.ac.ir/index.php/jthc/article/view/316 https://rhythm.tums.ac.ir/index.php/jthc/article/download/316/309