Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 9 4 2015 10 13 186 190 EN Seyed Hossein Ahmadi Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Mahmood Shirzad Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Sam Zeraatian Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Abbas Salehiomran Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Seyed Hesameddin Abbasi Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Atefeh Ghiasi Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 13 2015 10 13 Central venous catheter (CVC) insertion is a practical way to assess patients hemodynamic specially in cardiovascular surgery but this relatively simple junior level procedure is not risk free and its common reported complications include; pneumothorax, hydrothorax, hemothorax, local hematoma, cardiac tamponade, vascular injury, thrombosis, embolism, and catheter disruption. Here in this article we are going to present 6 patients with very unusual presentation of CVC complication which was neurological deficit presented by agitation , unconsciousness, disorientation to time and place and  hemiparesis. All patients undergone neurologic consult and brain computed tomography. Final diagnosis was brain ischemic damage and finally we kept them on conservative management; fortunately we did not have any permanent damage. https://rhythm.tums.ac.ir/index.php/jthc/article/view/355 https://rhythm.tums.ac.ir/index.php/jthc/article/download/355/348