Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 10 4 2016 03 15 205 207 EN Abbasali Rafighdust Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Ali Eshraghi Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. 2015 12 19 2015 12 19 The invention of the drug-eluting stent (DES) has brought about revolutionary changes in the field of interventional cardiology. In the DES era, in-stent restenosis has declined but new issues such as stent thrombosis have emerged. One of the emerging paradigms in the DES era is stent fracture. There are reports about stent fracture leading to in-stent restenosis or stent thrombosis. Most of these reports concern the Sirolimus-eluting stent. The present case is a representation of a Biolimus-eluting stent fracture. We introduce a 64-year-old male patient, for whom the BioMatrix stent was deployed in the right coronary artery. Five months after the implantation, he experienced acute myocardial infarction, with stent fracture leading to stent thrombosis being the causative mechanism. Another DES (Cypher) was used to manage this situation, and the final result was good. https://rhythm.tums.ac.ir/index.php/jthc/article/view/448 https://rhythm.tums.ac.ir/index.php/jthc/article/download/448/397