Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 2 2 2007 04 15 77 80 Hosein Vakili Cardiovascular Research Center, Modarres Hospital, Shaheed Beheshti University of Medical Sciences Ali Mir Cardiovascular Research Center, Modarres Hospital, Shaheed Beheshti University of Medical Sciences Mohammad Hasan Namazi Cardiovascular Research Center, Modarres Hospital, Shaheed Beheshti University of Medical Sciences, Habibollahe Saadat Cardiovascular Research Center, Modarres Hospital, Shaheed Beheshti University of Medical Sciences, Morteza Safi Cardiovascular Research Center, Modarres Hospital, Shaheed Beheshti University of Medical Sciences, Mohammad Reza Motamedi Cardiovascular Research Center, Modarres Hospital, Shaheed Beheshti University of Medical Sciences, Roxana Sadeghi Cardiovascular Research Center, Modarres Hospital, Shaheed Beheshti University of Medical Sciences, 2015 10 03 Background: This study was designed to examine a unique and low dose use of intravenous enoxaparin in elective percutaneous coronary intervention (PCI) that would be applicable to an unselected population regardless of age, weight, and renal function. There is limited experience in anticoagulation using intravenous low-molecular-weight heparin in PCI. Methods: A total of 100 consecutive patients undergoing elective PCI were treated with a single IV bolus of enoxaparin (0.5mg/kg) in group A of patients (n=50) or with unfractionated heparin in group B of patients (n=50). Sheaths were removed immediately after the procedure in patients treated with enoxaparin and some hours later in those treated with unfractionated heparin. Results: In group A, ACT was 124.6±9.3 before PCI and 149.2±17.1 after that (P<0.05). In group B, one patient (2.9%) developed groin hematoma. No deaths, MI, or urgent target vessel revascularization were reported. Conclusion: Low- dose (0.5 mg/kg) IV enoxaparin allows a target level of anticoagulation in patients undergoing PCI, appears to be safe and effective, allows immediate sheath removal, and does not require dose adjustment. https://rhythm.tums.ac.ir/index.php/jthc/article/view/45 https://rhythm.tums.ac.ir/index.php/jthc/article/download/45/43