Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 12 4 2018 02 24 188 191 EN Reza Ghanavati Department of Cardiovascular Medicine, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. Ali Amiri Shahid Beheshti University of Medical Sciences, Tehran, Iran. Nafiseh Ansarinejad Department of Hematology and Medical Oncology, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. Shokoufeh Hajsadeghi Department of Cardiovascular Medicine, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. Hasan Riahi Beni Department of Cardiovascular Medicine, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Seyyed Hashem Sezavar Department of Cardiovascular Medicine, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. 2016 09 20 2017 02 12 Superior vena cava (SVC) syndrome is a medical condition resulting from the obstruction of the blood flow through the large central veins. Recently, central venous catheters have been reported as the increasingly common cause of this syndrome. We describe a 56-year-old woman with previous history of metastatic colon cancer, who had recently undergone central venous catheter insertion for her second chemotherapy course. Eight days following port insertion, she presented with signs and symptoms suggestive of acute SVC syndrome, which was successfully managed with catheter-directed thrombolysis. The pre-discharge transesophageal echocardiography and conventional angiography showed a patent SVC. The patient was discharged and remained asymptomatic over a 6-month follow-up. This case shows that catheter-directed thrombolysis may be used as a safe treatment for catheter-induced acute SVC syndrome in patients who have undergone catheter insertion in the central vein.  https://rhythm.tums.ac.ir/index.php/jthc/article/view/609 https://rhythm.tums.ac.ir/index.php/jthc/article/download/609/610