Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 11 3 2016 11 08 143 148 EN Saeed Alipour-Parsa Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Elham Farahani Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2016 10 25 2016 10 25 The acute coronary syndrome due to the left main coronary artery (LMCA) thrombosis is a clinically rare and catastrophic event.  We describe a young man (smoker, alcoholic, and drug abuser) with a history of recent surgery and typical chest pain who had non-occlusive LMCA thrombosis in coronary angiography. The thrombosis was successfully treated with two 180 µ/kg intracoronary boluses of eptifibatide, which was continued through an intravenous infusion at 2 µ/kg/min for 48 hours postprocedurally. Control angiography, performed 3 days later, revealed that the LMCA was free of thrombosis. The patient had no complaints, including chest pain, and remained completely asymptomatic during the next 30 days' follow-up. https://rhythm.tums.ac.ir/index.php/jthc/article/view/621 https://rhythm.tums.ac.ir/index.php/jthc/article/download/621/476