Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 14 2 2019 03 14 47 52 EN Jan Guelker Department of Cardiology, Heart Centre Niederrhein, Helios Clinic Krefeld, Krefeld, Germany. AND Institute for Heart and Circulation Research, University Cologne, Cologne, Germany. Lars Bansemir Department of Cardiology, Heart Centre Niederrhein, Helios Clinic Krefeld, Krefeld, Germany. AND Institute for Heart and Circulation Research, University Cologne, Cologne, Germany. Rainer Ott Department of Cardiology, Heart Centre Niederrhein, Helios Clinic Krefeld, Krefeld, Germany. AND Institute for Heart and Circulation Research, University Cologne, Cologne, Germany. Thomas Rock Department of Cardiology, Heart Centre Niederrhein, Helios Clinic Krefeld, Krefeld, Germany. AND Institute for Heart and Circulation Research, University Cologne, Cologne, Germany. Rosemarie Guelker RWI-Leibniz-Institute for Economic Research, Essen, Germany. Dong-In Shin Department of Cardiology, Heart Centre Niederrhein, Helios Clinic Krefeld, Krefeld, Germany. AND Institute for Heart and Circulation Research, University Cologne, Cologne, Germany. Heinrich Klues Department of Cardiology, Heart Centre Niederrhein, Helios Clinic Krefeld, Krefeld, Germany. AND Institute for Heart and Circulation Research, University Cologne, Cologne, Germany. Alexander Bufe Department of Cardiology, Heart Centre Niederrhein, Helios Clinic Krefeld, Krefeld, Germany. AND Institute for Heart and Circulation Research, University Cologne, Cologne, Germany. AND Witten/Herdecke University, Witten, Germany. 2016 12 14 2018 10 09 Background: Percutaneous coronary intervention (PCI) of total chronic coronary occlusions (CTOs) still remains a major challenge in interventional cardiology. There is little knowledge in the literature about differences in CTO-PCI between diabetic and nondiabetic patients in the era of third-generation drug-eluting stents (DESs). In this study, we analyzed the impact of diabetes mellitus (DM) on procedural characteristics, complications, and acute outcomes in a cohort of 440 patients. Methods: Between 2012 and 2016, we recruited 440 consecutive patients, 116 of them with DM. All the patients underwent PCI for at least 1 CTO. Antegrade and retrograde CTO recanalization techniques were applied. Only third-generation DESs were used. We used t-tests and the Pearson chi-quadrat test to test the significant differences in the variables between the 2 groups. Results: The patients with DM were older than the nondiabetics (64.5 y vs. 61.1 y; P=0.003), and they suffered more frequently from a chronic kidney disease (7.1% vs. 2.4%; P=0.001). The nondiabetics less frequently had arterial hypertension (75.3% vs. 89.7%; P=0.001); however, they more often had a family liability for CAD (32.1% vs. 22.4%; P=0.050) and had a higher left ventricular  ejection fraction (59.2% vs. 56.7%; P=0.011). The success rate was 85.2% in the patients without DM and 81.2% in the patients with DM (P=0.403). The existence of DM had no impact on the procedural success and complication rates. Conclusion: Our study on 440 patients shows that diabetics and nondiabetics have similar success and complication rates after the recanalization of CTOs using third-generation DESs. It is a feasible and safe procedure and can be recommended as an alternative treatment. https://rhythm.tums.ac.ir/index.php/jthc/article/view/637 https://rhythm.tums.ac.ir/index.php/jthc/article/download/637/831