Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 12 4 2018 02 24 155 159 EN Shervin Assari Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA. AND Center for Research on Ethnicity, Culture and Health, School of Public Health, University of Michigan, Ann Arbor, MI, USA. Hassan Zandi Medicine and Health Promotion Institute, Tehran, Iran. Khodabakhsh Ahmadi Behavioral Sciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Davoud Kazemi Saleh Behavioral Sciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. 2017 10 19 2017 10 19 Background: The association between coronary angiographic findings and the level of anxiety symptoms among patients who undergo coronary angiography is not known. The aim of this study was to investigate the association between the extent of coronary stenosis and anxiety symptoms in patients who undergo coronary angiography. Methods: In a cross-sectional study, 106 patients who underwent coronary angiography and had varying degrees of coronary artery disease were enrolled. Demographic characteristics (i.e., age and gender), socioeconomic status (i.e., educational attainment, income, and marital status), and traditional risk factors (i.e., hypertension, diabetes mellitus, hyperlipidemia, and smoking) were measured. The independent variable was the extent of coronary stenosis shown by coronary angiography, coded as single-vessel disease (n = 19), 2-vessel disease (n = 28), or 3-vessel disease (n = 59). The main outcome was symptoms of anxiety measured using the Hospital Anxiety Depression Scale (HADS). The Kruskal–Wallis test was used for bivariate analysis, and linear regression was applied for multivariable analysis. Results:  Participants were mostly men (n = 78, 73%), at a mean age of 50.14 ± 10.60 years. We found an inverse association between the extent of coronary stenosis and anxiety symptoms in our samples. Anxiety symptoms were lowest in the patients with 3-vessel disease and highest in those with single-vessel disease. The above association remained significant in a linear regression model, controlled for the demographic, socioeconomic, and traditional risk factors. Conclusion: An inverse association may exist between the extent of coronary stenosis and the severity of anxiety symptoms in patients who undergo coronary angiography. Patients who undergo angiography and have fewer angiographic findings require screening for anxiety symptoms. https://rhythm.tums.ac.ir/index.php/jthc/article/view/794 https://rhythm.tums.ac.ir/index.php/jthc/article/download/794/643