Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 1 2021 01 14 1 14 Atefeh Nasir Kansestani 1Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. 2Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Mohammad Erfan Zare 1Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. 2Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Jun Zhang Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. 2020 09 11 2021 01 18 Background: Several reports have determined that cardiovascular diseases (CVDs) are common complications in patients with coronavirus disease 2019 (COVID-19) and lead them to poor outcomes. CVD biomarkers have, thus, great potential to be used as prognostic biomarkers. We aimed to determine the accuracy of CVD biomarkers for the prognosis of the COVID-19 patient’s outcome via a diagnostic test accuracy (DTA) meta-analysis. Methods: Until September 30, 2020, we searched Web of Sciences, Scopus, and MEDLINE/PubMed databases to obtain related papers. The summary points and lines were calculated using bivariate/HSROC model. As outcomes, we considered critical conditions and mortality. Results: A total of 17 659 patients from 33 studies were included. Five biomarkers, namely increased levels of lactate dehydrogenase (LDH), cardiac troponin I (cTnI), creatine kinase (CK), D-dimer, and thrombocytopenia, met the inclusion criteria. Our results indicated that LDH and cTnI had good accuracy for the prognosis of critical condition (AUCHSROC=0.83 and 0.80, respectively), while LDH, cTnI, and D-dimer had acceptable accuracy (AUCHSROC=0.74, 0.71, and 0.72, respectively) for the prognosis of mortality. LDH and D-dimer had high sensitivity, whereas cTnI had high specificity. The other biomarkers did not have acceptable accuracy. Significant publication bias was found for D-dimer (P=0.053).   Conclusion: Among CVD biomarkers, LDH and cTnI had good accuracy for the prognosis of critical outcomes and acceptable accuracy for the prognosis of mortality, without publication bias. Given their different sensitivities and specificities, we recommend the use of these 2 biomarkers concomitantly.  https://rhythm.tums.ac.ir/index.php/jthc/article/view/1348 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1348/945

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 1 2021 01 14 15 19 EN Fariba Raygan School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Aniseh Etminan Students’ Research Center, Kashan University of Medical Sciences, Kashan, Iran. Hanieh Mohammadi Students’ Research Center, Kashan University of Medical Sciences, Kashan, Iran. Hossein Akbari School of Public Health, Kashan University of Medical Sciences, Kashan, Iran. hassan Nikoueinejad Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. 2018 06 30 2021 04 19 Background: Growth differentiation factor-15 (GDF-15), a member of transforming growth factors, is a stress-responsive marker whose levels may significantly increase in response to pathological stresses associated with inflammatory tissue injuries such as unstable angina pectoris (USAP). This study evaluated the diagnostic value of GDF-15 in patients with USAP. Methods: The present cross-sectional study recruited 39 patients with USAP criteria and 30 patients with stable angina pectoris (SAP), referred to Shahid Beheshti Hospital, Kashan, Iran. All the patients with USAP had at least 1 coronary artery stenosis (>50%) in angiography. The control group comprised 42 healthy individuals. The serum levels of GDF-15 were measured in all the participants by ELISA. Also analyzed were the relationship between GDF-15 levels and thrombolysis in myocardial infarction (TIMI) and the Global Registry of Acute Coronary Events (GRACE) risk scores in the patients with USAP to determine the severity of the disease. Result: The study population consisted of 111 subjects, 62 women and 49 men, divided into 3 groups of USAP (n=39, mean age=60.07±14.10 y), SAP (n=30, mean age=67.56±9.88 y), and control (n=42, mean age=61.21±7.76 y). The mean serum level of GDF-15 in the USAP group was significantly different from the other 2 groups (P<0.001), while no significant difference was observed in this regard between the SAP and control groups (P=0.797). No correlation was found between the mean GDF-15 serum level and the GRACE (P=0.816) and TIMI (P=0.359) risk scores in the USAP group. Conclusion:  The mean serum level of GDF-15 exhibited a rise in our patients with USAP. GDF-15 may be a diagnostic biomarker of USAP and its severity. https://rhythm.tums.ac.ir/index.php/jthc/article/view/914 https://rhythm.tums.ac.ir/index.php/jthc/article/download/914/946

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 1 2021 01 14 20 25 Hilal Erken Pamukcu Dışkapı Yıldırım Beyazıt Training and Research Hospital, University of Health Sciences, Ankara, Turkey. Veysel Ozan Tanık Dışkapı Yıldırım Beyazıt Training and Research Hospital, University of Health Sciences, Ankara, Turkey. Barış Şimşek Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul, Turkey. İbrahim Hakan Güllü Dışkapı Yıldırım Beyazıt Training and Research Hospital, University of Health Sciences, Ankara, Turkey. 2020 08 13 2021 05 05 Background: Atrial fibrillation (AF) is associated with increased morbidity in myocardial infarction (MI), especially thromboembolic risk increases. The PRECISE-DAPT (The PREdicting bleeding Complications In patients undergoing Stent implantation and subsEquent Dual Anti-Platelet Therapy) score was created to predict the bleeding risk of dual antiplatelet therapy. The purpose of this study was to evaluate the association between new-onset AF and the PRECISE-DAPT score in ST-segment-elevation myocardial infarction (STEMI). Methods: This retrospective study enrolled patients who developed STEMI within 12 hours of the onset of symptoms and underwent primary percutaneous coronary intervention. The study population was divided into 2 groups of PRECISE-DAPT scores of 25 or greater and PRECISE-DAPT scores of below 25 and their baseline characteristics, as well as laboratory and echocardiography results, were compared. In-hospital new AF and related events were compared between the 2 PRECISE-DAPT score groups. Results: From February 2015 to December 2017, this study enrolled 2234 patients with STEMI at a mean age of 54.4 years. The new-onset AF incidence rate was higher in the higher PRECISE-DAPT group than in the lower PRECISE-DAPT group (62 [28.7 %] vs 58 [2.9%]; P<0.001). According to the multivariate logistic regression analysis, the factors associated with new-onset AF were the left atrial diameter (OR =1.98, 95% confidence interval= 1.34–2.93; P=0.001) and the PRECISE-DAPT score (OR =1.04, 95% confidence interval= 1.10–1.18; P<0.001). Conclusion: The PRECISE-DAPT score was associated with the development of new-onset AF in our patients with STEMI. Further follow-up of these patients will provide clearer information. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1332 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1332/948

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 1 2021 01 14 26 30 Yaser Jenab Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Hamid Ariannejad Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Zahra Rabbani School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Faezeh Soveyzi School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Ali HosseinSabet Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Shapour Shirani Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. 2020 08 15 2021 05 08 Background: The right heart thrombus (RHT) embolizes from deep venous thrombi and sits in the right atrium or the right ventricle. We aimed to determine the occurrence and prognosis of the RHT in patients with pulmonary embolism. Methods: We reviewed the cohort data of 622 patients with acute pulmonary embolism obtained from the registry of Tehran Heart Center. Demographic, physiological, clinical, and echocardiographic data, as well as clinical outcomes, were compared between patients with and without the RHT. Results: The study population comprised 622 patients, including 329 men (52.8%). The mean age of the patients was 60.2±17.0 years. Thirty patients (4.8%) had echocardiographically proven RHT. Baseline demographic and clinical characteristics were not different between the 2 groups. Right ventricular dysfunction was more prevalent in the RHT (+) group, and more patients in this group were treated with thrombolysis (P=0.013 and P<0.001, respectively). Overall, 3 out of 21 patients (14.2%) in the RHT (+) group vs 29 out of 306 patients (9.4%) in the RHT (−) group died at 1 month (P=0.445) and 5 out of 21 patients (23.8%) in the RHT (+) group vs 56 out of 307 patients (18.2%) in the RHT (−) group died at 1 year (P=0.562). Conclusion: The RHT is an influential complication in patients with pulmonary emboli, and it seems to increase the mortality rate of patients with acute pulmonary embolism. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1333 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1333/949

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 1 2021 01 14 31 33 Hakimeh Sadeghian Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Afsaneh Sadeghian Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Bahare Eslami Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Seyed Hesameddin Abbasi 1Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. 2Bernard Lown Scholar in Cardiovascular Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Masoumeh Lotfi-Tokaldany Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. 2020 09 07 2021 01 30 Mucopolysaccharidosis (MPS) syndrome is an inherited metabolic disorder. In more than half of the patients with MPS syndrome, heart valve involvement is reported; however, combined aortic and mitral valve stenosis in MPS syndrome type I-S is very rare. We describe a 39-year-old man with severe mitral and aortic valve stenosis due to MPS syndrome type I-S. Transthoracic and transesophageal echocardiography revealed severe thickening and calcification in the aortic and mitral valves with severe left ventricular hypertrophy. The coronary arteries were normal in angiography. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1342 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1342/960

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 1 2021 01 14 34 37 Noor Mohamad Noori Children and Adolescents Health Research Center, Ali-Ibn-Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran. Seyed Hosein Solemanzadeh Mousavi Ali-Ibn-Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran. Changiz Azadi Ahmadabadi Ali-Ibn-Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran. 2020 10 09 2021 01 28 Sharp-object penetration into the chest is rare and may lead to life-threatening complications, hence the significance of early detection and removal. We present an uncommon case of the accidental penetration of a sewing needle into the chest of a 5-year-old girl, with the needle traveling from the entrance site to the right ventricle through the lung tissue. Due to the possibility of cardiovascular accidents, the patient was transferred to a special ward. For positioning and correct actions, TTE and CT scan of the chest with and without contrast were performed and the presence of a tangential needle with the right ventricular wall and inside the pericardium was reported. The patient was taken to the operating room, and after exploring, a 2 cm needle was inserted into the right ventricle and removed. The patient was discharged after 5 days. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1361 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1361/950

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 1 2021 01 14 38 41 Safieh Boroumand 1Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. 2Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Seyed Hossein Ahmadi-Tafti Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Saeed Davoodi Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Seyed Khalil Forouzannia Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. 2020 11 28 2021 02 18 Open total arch replacement is allied to high rates of mortality and morbidity; surgeons, therefore, tend to choose hybrid aortic arch repair as a less invasive operative procedure for the treatment of aortic arch aneurysms, especially in high-risk patients. However, studies on the early and late outcomes of patients undergoing hybrid aortic arch repair have revealed high rates of reintervention and reoperation compared with open total arch replacement. Here, we describe a male patient with late retrograde aortic dissection after hybrid thoracic endovascular aortic repair for aortic arch aneurysms. The patient returned 3 years after the procedure with signs of dyspnea on exertion and chest pain. Transthoracic echocardiography and computed tomography showed dissection of the ascending aorta, for which he underwent a redo Bentall procedure. The patient was weaned from cardiopulmonary bypass without any problem and discharged after 7 days. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1381 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1381/951

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 1 2021 01 14 42 44 Meisam Mokhtari 1-Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 2-Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Zahra Khajali Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Mona Heidarali Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Majid Haghjoo Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 2-Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 2020 07 17 2021 04 05 Atrial fibrillation (AF) is the most commonly treated arrhythmia in clinical practice and is often found in association with an atrial septal defect (ASD). However, ASD closure rarely confers complete arrhythmia control. A 23-year-old man presented to our center with frequent episodes of palpitations. AF was documented in 12-lead electrocardiography, and echocardiography showed a secundum-type ASD, 14 mm in size, with a significant left-to-right shunt. ASD closure was performed successfully with an ASD occluder device with no residual shunting. During follow-up, the patient experienced several episodes of AF. Thirteen months after the ASD closure, cryoballoon pulmonary vein isolation was done successfully with no complications. During a 12-month follow-up, he had no symptoms or AF recurrences, and echocardiography showed no residual shunting. This study showed that cryoballoon pulmonary vein isolation could be performed successfully without residual shunts in patients with ASD closure devices. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1320 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1320/952

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 1 2021 01 14 45 46 Tufan Çınar Department of Cardiology, Sultan Abdülhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Suha Asal Department of Cardiology, Sultan Abdülhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Vedat Çiçek Department of Cardiology, Sultan Abdülhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Murat Selçuk Department of Cardiology, Sultan Abdülhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Muhammed Keskin Department of Cardiology, Sultan Abdülhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Ahmet Orhan Department of Cardiology, Sultan Abdülhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. 2021 01 22 2021 04 19 Not required. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1410 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1410/961

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 1 2021 01 14 47 48 Ali Hosseinsabet Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. 2020 03 25 2020 06 01 - https://rhythm.tums.ac.ir/index.php/jthc/article/view/1258 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1258/959

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 1 2021 01 14 49 50 Yavuzer Koza Atatürk University Gökhan Ceyhun Atatürk University Oğuzhan Birdal Atatürk University Hakan Taş Atatürk University 2020 09 21 2021 01 28 Not applicable https://rhythm.tums.ac.ir/index.php/jthc/article/view/1356 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1356/958