Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 2 2021 04 30 51 57 Shahram Moradi Kurdistan University of Medical Sciences, Sanandaj, Iran. Ghobad Moradi Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. Bakhtiar Piroozi Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. 2021 01 05 2021 09 09 Background: Calculating the burden of diseases is essential for their monitoring. The burden of cardiovascular diseases in Kurdistan Province has not been reported. This study aimed at calculating the burden of cardiovascular diseases in the Kurdistan Province from 2011 through 2017. Methods: In this cross-sectional study, incidence data were extracted from registration systems. The methods of the World Health Organization (WHO) were employed to calculate disability-adjusted life years (DALYs) of cardiovascular diseases in the Kurdistan Province. DALYs were calculated by summing the years of life lost (YLLs) and the years of life lived with disability (YLDs) for sex, age group, and year. Results: The burden of cardiovascular diseases increased from 18569.1 DALYs in 2011 to 34929.8 DALYs in 2017. The highest increase and the largest decrease in DALY according to the all age-standardized DALYs index were related to acute myocardial infarction and heart failure in women, respectively. The highest DALYs in both sexes were in the age group of over 80 years. Conclusion: The burden of cardiovascular diseases is increasing in the Iranian province of Kurdistan. It is, therefore, essential to implement appropriate and adequate interventions such as lifestyle modification, extensive screening, public education promotion, and operational plan development. We hope our results will aid decision-makers in performing urgent interventions. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1404 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1404/962

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 2 2021 04 30 75 78 Mohammad Khani Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Morteza Abdar Esfahani Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran. Fariba Bayat Cardiovascular Research Center, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Alireza Khalaj Department of Cardiac Surgery, Shahed University of Medical Sciences, Tehran, Iran. Abdolhamid Bagheri Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2019 10 25 2021 09 04 Tricuspid valve myxomas are very uncommon tumors that could be found after the occurrence of pulmonary thromboembolism, symptomatic tricuspid obstruction, and right-sided heart failure.  Herein, we describe a 42-year-old woman evaluated for an abdominal mass. In preoperative consultation, a tricuspid valve mass was detected in echocardiography. She underwent the removal of a benign uterine myoma and a myxoma of the tricuspid valve. Tricuspid valve myxomas constitute a scarce diagnosis. They could be asymptomatic, occurring in unusual locations and in association with benign tumors in other organs. Our patient was asymptomatic, underscoring the significance of the early diagnosis of this type of tumor to prevent further catastrophic events. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1175 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1175/965

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 2 2021 04 30 89 91 Zahra Alizadeh-Sani 1-Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 2-Omid Hospital, Iran University of Medical Sciences, Tehran, Iran. Ali Hosseinsabet Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. 2020 09 10 2021 07 08 - https://rhythm.tums.ac.ir/index.php/jthc/article/view/1346 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1346/972

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 2 2021 04 30 58 67 Niloufar Samiei Heart Valve Disease Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Fatemeh Abbasi Department of Cardiology, Chamran Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. Maryam Shojaeifard Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Mozhgan Parsaee Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Saeid Hosseini Heart Valve Disease Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Yousef Rezaei Heart Valve Disease Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Nasim Naderi Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 2020 07 03 2021 09 04 Background: The frequency of left ventricular diastolic dysfunction (DD) is overestimated by earlier recommendations. We compared the 2009 and 2016 guidelines regarding the detection of DD and explored the potential of adding left atrial (LA) strain to the current guideline. Methods: Consecutive patients with heart failure were enrolled. All the patients were examined using 2-dimensional speckle-tracking echocardiography (2D-STE) and tissue Doppler imaging. DD was evaluated in terms of E/eʹ, eʹ velocity, E, A, tricuspid regurgitation velocity, LA volume, and LA strain. Results: This study evaluated 147 patients (101 males, 68.7%) at a mean age of 54.73±14.42 years. LA strain decreased with increasing grades of DD in both guidelines. The rate of reclassification between the 2 guidelines was 41%. The detection rate of normal diastolic function increased after the implementation of the 2016 guideline. LA strain discriminated individuals with normal diastolic function from those with DD more accurately than did LA volume index (area under the curve [AUC] =0.816 vs AUC=0.759, respectively). When LA strain <23% was incorporated into the 2016 guideline, 2 out of 4 patients with indeterminate diastolic function were reclassified as normal and 2 patients as grade I DD. The rate of reclassification was 4.1% after the addition of LA strain to the current guideline (κ=0.939, P<0.001). Conclusion: This study showed that the current guideline detected lower rates of DD than did the earlier recommendations. Furthermore, the incorporation of LA strain into the current guideline resulted in lower rates of indeterminate diastolic function. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1310 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1310/963

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 2 2021 04 30 79 83 EN Maria Shirvani Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Babak Sayad Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Lida Shojaei Department of Clinical Pharmacy, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran. Azadeh Amini Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Foroud Shahbazi Department of Clinical Pharmacy, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran. 2021 03 11 2021 05 24 Recently, remdesivir was approved by the United States Food and Drug Administration for patients with Coronavirus disease 2019 (COVID-19). We herein describe 3 patients with COVID-19 who showed significant bradycardia and QTc prolongation after remdesivir administration. Bradycardia did not respond to atropine treatment in 2 of the patients, one of whom received theophylline and the other required a temporary pacemaker. Fortunately, the patients’ heart rate and rhythm returned to normal after the discontinuation of remdesivir, albeit it lengthened their hospital stays. Careful monitoring during remdesivir infusion may decrease the risk of adverse cardiovascular side effects. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1433 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1433/966

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 2 2021 04 30 92 94 EN Arezoo Zoroufian Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Ali vasheghani-Farahani Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. AND Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Neda Toofaninejad Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. 2021 05 09 2021 08 15 - https://rhythm.tums.ac.ir/index.php/jthc/article/view/1402 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1402/971

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 2 2021 04 30 68 74 Samaneh Mozaffarian School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Korosh Etemad Environmental and Occupational Hazard Control Research Center, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohammad Aghaali School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Soheila Khodakarim School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Sahar Sotoodeh Ghorbani School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Seyed Saeed Hashemi Nazari Prevention of Cardiovascular Disease Research Center, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2021 01 12 2021 09 09 Background: Coronary artery disease is the most common cause of death worldwide as well as in Iran. The present study was designed to predict short and long-term survival rates after the first episode of myocardial infarction (MI). Methods: The current research is a retrospective cohort study. The data were collected from the Myocardial Infarction Registry of Iran in a 12-month period leading to March 20, 2014. The variables analyzed included smoking status, past medical history of chronic heart disease, hypertension, diabetes, hyperlipidemia, signs and symptoms during an attack, post-MI complications during hospitalization, the occurrence of arrhythmias, the location of MI, and the place of residence. Survival rates and predictive factors were estimated by the Kaplan–Meier method, the log-rank test, and the Cox model. Results: Totally, 21 181 patients with the first MI were studied. There were 15 328 men (72.4%), and the mean age of the study population was 62.10±13.42 years. During a 1-year period following MI, 2479 patients (11.7%) died. Overall, the survival rates at 28 days, 6 months, and 1 year were estimated to be 0.95 (95% CI: 0.95 to 0.96), 0.90 (95% CI: 0.90 to 0.91), and 0.88 (95% CI: 0.88 to 0.89). After the confounding factors were controlled, history of chronic heart disease (p<0.001), hypertension (p<0.001), and diabetes (p<0.001) had a significant relationship with an increased risk of death and history of hyperlipidemia (p<0.001) and inferior wall MI (p<0.001) had a significant relationship with a decreased risk of death. Conclusion: The results of this study provide evidence for health policy-makers and physicians on the link between MI and its predictive factors. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1406 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1406/964

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 16 2 2021 04 30 84 88 Saeed Ghodsi Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Yaser Jenab Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Mehrnaz Mohebi Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Hosein Kamranzadeh Hematology-Oncology and Stem Cell Transplantation Research Center, Shariati Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Zohre Mohammadi Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. 2020 03 06 2021 05 24 Thrombotic thrombocytopenic purpura (TTP) is a multisystem disorder that frequently manifests itself with renal and neurological involvements. Cardiac involvement, however, has been rarely reported. In this report, we present a rare case of acquired TTP with acute myocardial infarction (AMI) as the initial manifestation. Although AMI was successfully managed by percutaneous coronary intervention, the patient developed hemolytic anemia, fever, marked thrombocytopenia, oliguria, and renal dysfunction, requiring treatment with plasma exchange and corticosteroids. TTP, albeit extremely rare, should be considered in cases with unexpected thrombocytopenia during acute-phase treatment for AMI as it can be highly lethal if not treated immediately. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1246 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1246/967