Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 1 2022 01 30 1 6 Mehrab Marzban Cardiovascular Outcomes Research Laboratories (CORELAB), Division of Cardiac Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Peyman Benharash Cardiovascular Outcomes Research Laboratories (CORELAB), Division of Cardiac Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. 2021 08 30 2021 10 30 No Abstract No Abstract No Abstract https://rhythm.tums.ac.ir/index.php/jthc/article/view/1514 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1514/994

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 1 2022 01 30 7 14 Shima Jafari Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran. Azita Talasaz Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. -Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Abbas Salehiomran Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Hamid Ariannejad Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Arash Jalali Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. 2020 06 16 2022 04 09 Background: Preoperative anemia is an independent risk factor for higher rates of blood transfusion in cardiac surgery. This study aimed to evaluate the effects of intravenous iron sucrose and erythropoietin on transfusion requirements in patients with preoperative iron deficiency anemia (IDA) undergoing on-pump coronary artery bypass graft (CABG) surgery. Methods: In this open-label, randomized clinical trial, patients with preoperative IDA who were candidates for on-pump CABG were randomized into intervention (iron plus erythropoietin) or control groups. Iron sucrose was administered as a 200 mg intravenous dose and erythropoietin as a 100 IU/kg bolus 1 to 2 days before surgery. The primary outcome was the amount of blood transfusion during the first 4 postoperative days. Results: The study population consisted of 114 patients. The mean age was 64.11±8.18 years in the intervention group and 63.35±8.70 years in the control group. Twenty-seven patients (47.4%) in the intervention group and 25 (43.9%) in the control group were males. The number of red blood cell units transfused per patient exhibited a significant fall in the intervention group compared with the control group (P˂0.001). The ferritin level showed a significant rise in the intervention group on postoperative day 7 (P=0.027). The length of stay in the intensive care unit and the hospital was significantly lower in the intervention arm (P=0.041 and P=0.006, respectively). No adverse events were reported in both groups. Conclusion: The use of erythropoietin and iron sucrose 1 to 2 days before surgery significantly decreased the need for blood transfusion in patients with IDA undergoing CABG without any significant adverse events. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1300 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1300/995

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 1 2022 01 30 15 21 Firoozeh Madadi Anesthesiology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Marjan Aghajani Department of physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Ali Dabbagh Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Kamal Fani Anesthesiology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Fardin Sehati Department of physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Alireza Imani - Department of physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. - Occupational Sleep Research Center, Tehran University of Medical Sciences, Tehran, Iran. 2021 08 30 2022 03 03 Background: Acute myocardial infarction is an important cause of morbidity. This study aimed to investigate the effects of the administration of potassium chloride (KCl) on reperfusion-induced injuries in a rat model of myocardial ischemia/reperfusion. Methods: Thirty-six male Wistar rats, weighing 200 to 250 g, were randomly assigned to 3 experimental groups: control, K1 (10 µg/kg of KCl), and K2 (20 µg/kg of KCl). Twenty minutes before ischemia, a single dose of 10 and 20 µg/kg of KCl was intraperitoneally administered in the K1 and K2 groups, respectively. The coronary artery was occluded for 30 minutes (ischemia); thereafter, it was opened for 60 minutes (reperfusion) to measure hemodynamic parameters and ventricular arrhythmias. Blood sampling was performed after the reperfusion period to determine the serum levels of lactate dehydrogenase, troponin I, creatine kinase (CK)-MB, malondialdehyde, and pro-oxidant-antioxidant balance. Results: Serological parameters significantly decreased in the potassium groups compared with the control group. In particular, the decline was more pronounced for the serum levels of lactate dehydrogenase (1180.25±69.48 vs 1556.67±77.02 U/L; P=0.011), troponin I (21.98±0.61 vs 28.76±1.65 ng/mL; P=0.020), and pro-oxidant-antioxidant balance (15.51±0.72 vs 20.63±1.42 HK; P=0.041) in the K2 group compared with the K1 group. Moreover, the administration of 20 µg/kg of KCl significantly decreased the incidence of ventricular tachycardias and fibrillations compared with the control group (P=0.002). Additionally, no considerable differences were observed between the control group and the groups with 10 µg/kg and 20 µg/kg of KCl regarding the number of ventricular ectopic beats.  Conclusion: The administration of KCl before ischemia could reduce ventricular arrhythmias and reperfusion-induced injuries by reducing oxidative stress. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1515 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1515/996

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 1 2022 01 30 22 25 Naga ganesh kumar kasinadhuni Advanced Cardiac Centre, Post Graduate Institute of Medical, Education and Research, Chandigarh, INDIA. Krishna Prasad Advanced Cardiac Centre, Post Graduate Institute of Medical, Education and Research, Chandigarh, INDIA. Rajesh Vijayvergiya Advanced Cardiac Centre, Post Graduate Institute of Medical, Education and Research, Chandigarh, INDIA. Tejinder Malhi Advanced Cardiac Centre, Post Graduate Institute of Medical, Education and Research, Chandigarh, INDIA. 2021 04 25 2022 03 03 Severe Coronavirus disease 2019 (COVID-19) infection presents with acute respiratory distress syndrome and multiorgan dysfunction. Cardiac involvement is seen in about a quarter of patients, and it can present as acute coronary syndromes, arrhythmias, myocarditis, and thromboembolic events. Ventricular arrhythmias in the setting of COVID-19 infection are usually multifactorial in etiology.  There are only a few reports of ventricular tachycardia (VT) storms in patients with COVID-19 infection.  We hereby report a case of an elderly man with severe left ventricular systolic dysfunction and a stable cardiac status for the last few years who, following coronary artery bypass graft surgery and implantable cardioverter-defibrillator (ICD) implantation, experienced a VT storm after a COVID-19 infection. The VT storm was controlled using multiple ICD shocks, along with antiarrhythmic drugs. Following his recovery from COVID-19 infection, the patient was asymptomatic at a 3-month follow-up. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1450 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1450/997

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 1 2022 01 30 26 28 EN Nikolaos Schizas Department of Cardio Thoracic and Vascular Surgery, Evangelismos General Hospital of Athens, Athens, Greece. Vasilios Patris Department of Cardio Thoracic and Vascular Surgery, Evangelismos General Hospital of Athens, Athens, Greece. Ilias Samiotis Department of Cardio Thoracic and Vascular Surgery, Evangelismos General Hospital of Athens, Athens, Greece. Eleni Nikoli Department of Anesthesiology, Evangelismos General Hospital of Athens, Athens, Greece. Niki Lama Research Unit of Radiology and Medical Imaging, Kapodistrian University of Athens, Athens, Greece. Michail Argiriou Department of Cardio Thoracic and Vascular Surgery, Evangelismos General Hospital of Athens, Athens, Greece. 2021 04 26 2022 02 16 Ligation of the left innominate vein (LIV) expands the surgeon’s surgical field for ascending aorta and aortic arch procedures. Although it is considered a safe technique by most surgeons in that it is associated with only minor drawbacks, conflicting views exist regarding this method. We herein describe a 70-year-old woman who underwent ascending aorta replacement due to an aneurysm with subsequent cerebral dysfunction caused by extended brain edema, possibly related to LIV ligation, leading to her death. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1451 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1451/998

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 1 2022 01 30 29 32 Mohammad Vojdanparast Razavi Hospital, Imam Reza International University, Mashhad, Iran. Azra Izanloo Razavi Cancer Research Center, Razavi Hospital, Imam Reza International University, Mashhad, Iran. Zahra Alizadeh Sani -Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. - Omid Hospital, Tehran, Iran. Roollalah Alizadehsani Institute for Intelligent Systems Research and Innovation, Deakin University, Geelong, VIC 3216, Australia. Sheikh Mohammed Shariful Islam Institute for Physical Activity and Nutrition, Deakin University, Melbourn, Australia 2020 11 14 2022 01 17 Coronaviruses can cause viral pneumonia with extrapulmonary manifestations and complications. Many patients have either underlying cardiovascular disease or cardiac risk factors. Acute heart attacks are also frequent in severe cases of coronavirus disease 2019 (COVID-19), which is associated with high mortality. In this paper, we describe a patient with COVID-19 who presented with myocardial infarction (MI) symptoms but lacked the initial symptoms of the infection such as fever and cough. COVID-19 and myocardial infarction were diagnosed. The patient underwent thrombolytic treatment and fully recovered. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1377 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1377/999

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 1 2022 01 30 33 37 EN Erfan Kazemi 1. Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. Hossein Sheibani Clinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical Sciences, Imam Ave., Shahroud, Iran 2021 08 19 2022 02 28 Coronary artery aneurysms (CAAs) are rare, and aneurysms of the left main coronary artery are extremely rare. Atherosclerosis is the main cause of CAAs. An 87-year-old man with atypical chest pain of 1 month’s duration presented to a hospital. Physical examinations of the patient’s cardiopulmonary system and vital signs were unremarkable. Electrocardiography showed a right bundle branch block and an atypical ST-segment elevation in the inferior leads. Coronary angiography demonstrated a huge aneurysm in the left main without any clots. Additionally, there were no remarkable findings in cardiac monitoring and spiral chest computed tomography scanning. Ultimately, after he received nitroglycerin, β-blockers, Ca++ channel blockers, Aspirin (ASA), and clopidogrel (Plavix), his pain was relieved. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1510 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1510/1000

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 1 2022 01 30 38 40 Alireza Golbabaei Department of Perinatology and Fetal Cardiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran Mohamad Majnoun Assistant Professor of Pediatric Cardiology, Tehran University of Medical Sciences, Children’s Medical Cente, Tehran . Iran Ehsan Aghaei Moghadam Associate Professor of Pediatric Cardiology Department of Pediatrics, School of Medicine Childrens Medical Center Tehran University of Medical Sciences, Tehran . Iran Azade Rastgar Assistant Professor of Perinatology, Department of Obstetrics and GynecologyTehran University of Medical Sciences, Shariati Hospital,Tehran.Iran Mahsa Naemi Assistant professor, OB-gyn Perinatalogist, Department of Obstetrics and Gynecology, Shariati hospital, Tehran university of medical sciences, Tehran, Iran 2020 09 12 2021 09 26 No Abstract No Abstract No Abstract https://rhythm.tums.ac.ir/index.php/jthc/article/view/1349 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1349/1001