Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 3 2022 07 28 88 90 Haleh Ashraf Cardiac Primary Prevention Research Center (CPPRC), Cardiovascular Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Sepideh Taghavi Heart Valve Disease Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Hossein Navid Tehran Heart Center, Cardiovascular Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. 2022 09 21 2022 09 28 No Abstrac No Abstrac No Abstrac https://rhythm.tums.ac.ir/index.php/jthc/article/view/1723 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1723/1022

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 3 2022 07 28 91 102 Farzad Kamali 1.Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 2.Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Majid Haghjoo 1.Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 2.Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Yeganeh Pasebani 1-Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 2-Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Abolfath Alizadehdiz 1-Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 2-Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Zahra Emkanjoo 1-Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 2-Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Amirfarjam Fazelifar 1-Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 2-Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Farzad Masoudkabir Cardiac Primary Prevention Research Center, Cardiovascular Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Ala Keykhavani 1-Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 2-Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Shabnam Madadi 1. Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 2.Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center,, Iran University of Medical Sciences, Tehran, Iran. 2021 05 26 2022 07 26 The catheter ablation of idiopathic ventricular arrhythmias is accepted as a first-line treatment as it successfully eliminates about 90.0% of such arrhythmias. One of the most challenging ventricular arrhythmias originates from the left ventricular summit (LVS), a triangular epicardial space with the left main bifurcation as its apex. This area accounts for about 14.0% of LV arrhythmias. The complex anatomy of this region, accompanied by proximity to the major epicardial coronary arteries and the presence of a thick fat pad in this region, renders it a challenging area for catheter ablation. This article presents a review of the anatomy of the LVS and relevant regions and discusses novel mapping and ablation techniques for eliminating LVS ventricular arrhythmias. Additionally, we elaborate on the electrocardiographic (ECG) manifestations of arrhythmias from the LVS and their successful ablation via the direct approach and the adjacent structures. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1474 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1474/1014

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 3 2022 07 28 103 111 Ata Firouzi Cardiovascular intervention research center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Zahra Hosseini Cardiovascular intervention research center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Zeinab Norouzi Cardiovascular intervention research center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Zohre Hosseini Cardiovascular intervention research center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Afshin Amirpour Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. Hamed Talakoob Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran. Arash Amin Lorestan Heart Center (Madani Hospital), Lorestan University of Medical Sciences, Khorram Abad, Lorestan, Iran. Abbas Soleimani Sina Hospital, Tehran University of Medical Sciences (TUMS), Thran, Iran. Nasrolah Moradifar Lorestan Heart Center (Madani Hospital), Lorestan University of Medical Sciences, Khorram Abad, Lorestan, Iran. Shahrokh Karbalai Sina Hospital, Tehran University of Medical Sciences (TUMS), Thran, Iran. Mohammadhosseini Mozafarybazargani Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran. Hamidreza Hekmat Ziaeian Hospital, International Campus, Tehran University of Medical Sciences, Tehran, Iran. Majid Maleki Cardiovascular intervention research center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Parham Sadeghipour Cardiovascular intervention research center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Seyedeh Mahnaz Mirbod Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. Mina Ghorbanpoor Kohnaki cardiovascular intervention research center, rajaie cardiovascular medical and research center Hooman Bakhshandeh Cardiovascular intervention research center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Masoomeh KalaeiNia Cardiovascular intervention research center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Fatemeh Sadat Habibizade Cardiovascular intervention research center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Sara Iraninejad Cardiovascular intervention research center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Mohammadreza Baay Cardiovascular intervention research center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. Ehsan Khalilipur Cardiovascular intervention research center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran. 2021 12 02 2022 08 24 Background There are limited data about the clinical outcomes of patients with coronavirus disease 2019 (COVID-19) who present with ST-Segment-Elevation Myocardial Infarction (STEMI). Objectives The aim of this multicenter study is to compare baseline clinical and procedural data between the case group (STEMI patients with COVID-19) and the control group (STEMI patients before the COVID-19 pandemic) and to determine in-hospital infarct-related artery thrombus grades; major adverse cardio-cerebrovascular events (MACCE), defined as a composite of deaths from any cause (cardiovascular and non-cardiovascular), nonfatal strokes, and stent thrombosis. Results There were no significant differences between two groups regarding baseline characteristics. Primary PCI was performed in 81% of the case group and 97% of the control group (P=0.043), and primary CABG was performed in 7% of the case group and 1.4% of the control group (P=0.04). The number of successful PCI procedures (final TIMI flow grade III) was significantly lower in the case group (66.5% vs 93%; P=0.0). The baseline thrombus grade before wire crossing was not statistically significantly different between the 2 groups. The summation of thrombus grades IV and V was 75% in the case group and 82% in the control group (P=0.43). The rate of MACCE was 17% and 2.1% in the case and control groups, correspondingly (P=0.002). Conclusions In our study, the thrombus grade had no significant differences between the case group and the control group; however, the in-hospital rates of the no-reflow phenomenon, periprocedural MI, mechanical complications, and MACCE were statistically significantly higher in the case group. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1564 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1564/1013

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 3 2022 07 28 112 118 Mohammad Sahebjam Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Alimohammad Haji Zeinali Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Kyomars Abbasi Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Solmaz Borjian Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. 2022 03 12 2022 07 21 Background: Transcatheter tricuspid valve-in-valve (TTViV) replacement has become an alternative treatment in high-risk patients with bioprosthetic valve degeneration. This is the first report on the mid to long-term echocardiographic findings of patients who underwent TTViV replacement in a cardiac referral center in Iran.   Methods: Data of 12 patients, consisting of 11 women and 1 man, who underwent TTViV replacement between 2015 and 2021 were reviewed retrospectively. The patients underwent echocardiography before the procedure and at a mean follow-up time of 3.17±1.75 years. Results: All the patients had New York Heart Association (NYHA) function class III/IV before TTViV. Six patients had tricuspid regurgitation, 1 had tricuspid stenosis, and 5 had both. All the patients had successful TTViV. The mean time from the initial valve surgery to TTViV was 6.25±2.45 years. At follow-up, 2 patients had died: 1 due to COVID-19 pneumonia and 1 without a known cause. The remaining 10 patients experienced improvements in the NYHA functional class. Echocardiographic measures showed significant improvements. Transvalvular mean gradient pressure decreased from 7.08±1.98 mm Hg to 5.29±1.63 mm Hg (P=0.028), tricuspid valve pressure half time decreased from 245.00±49.46 ms to 158.64±57.41 ms (P=0.011), tricuspid regurgitation gradient decreased from 39.91±7.31 mm Hg to 26.72±8.99 mm Hg, and left ventricular ejection fraction increased from 47.71±4.70% to 49.79±4.58% (P=0.046). There was no significant paravalvular or transvalvular leakage at follow-up. Conclusion: This is a single-center report on the mid and long-term echocardiographic follow-up of patients after TTViV replacement.  Our study showed that TTViV was a safe and efficient method in treating high-risk patients with degenerated bioprosthetic tricuspid valves and had favorable echocardiographic and clinical results. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1632 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1632/1015

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 3 2022 07 28 119 126 Saeedeh Asgarbeik Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Aida Vahidi Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Mandana Hasanzad 1- Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. 2- Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Mojgan Asadi Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Mahsa M.Amoli Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. 2021 10 30 2022 07 26 Background: In-stent restenosis (ISR) is an inevitable complication of percutaneous coronary intervention, with genetic factors thought to play a role in its pathogenesis. The VEGF gene can have an inhibitory effect on ISR development. Accordingly, in the present study, we investigated the role of −2549 VEGF (insertion/deletion [I/D]) variants in ISR formation. Methods: Patients with ISR (ISR+) (n=53) and patients without ISR (ISR-) (n=67) were enrolled in this case-control study based on follow-up angiography 1 year after percutaneous coronary intervention between 2019 and 2020. The clinical characteristics of the patients were evaluated, and the frequencies of the alleles and genotypes of −2549 VEGF (I/D) variants were determined using poly and assessments of existing data in the outpatient cardiology clinic. The comparative analysis was conducted using a logistic regression test. Results: The mean follow-up length was 66.26±15.32 months, 105 patients (52.2%) were male, and the mean age of the patients was 53.81±11.91 years. The left anterior descending was the main affected artery (42.8%). At long-term follow-up, 19 patients (9.5%) required repeated angiography. Three patients (1.5%) had a myocardial infarction and 5 (2.5%) died from cardiovascular etiologies. Three patients (1.5%) underwent percutaneous coronary intervention. No patient required coronary artery bypass grafting. The need for a second angiography had no association with sex, symptoms, and echocardiographic findings. Conclusion: The long-term outcome of CSF patients is good, but their follow-up is necessary for the early diagnosis of cardiovascular-related adverse events. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1593 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1593/1030

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 4 2022 10 31 207 214 Mohammad Javad Zibaeenezhad Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Mehrab Sayadi Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Seyyed Saeed Mohammadi Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Soorena Khorshidi Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Ehsan Hadiyan Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Neda Rasouli University of Colorado, School of Medicine, and VA Eastern Colorado Health Care system, Aurora, Colorado, USA Ali Karimi-Akhormeh Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Iman Razeghian-Jahromi Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 2022 01 23 2022 10 06 Background: This study aimed to investigate the possible relationship between different stent sizes and clinical outcomes after percutaneous coronary intervention (PCI) in patients with diabetes treated with drug-eluting stents (DESs) and dual antiplatelet therapy (DAPT). Methods: Patients with stable coronary artery disease undergoing elective PCI with the DES were entered into a retrospective cohort between 2003 and 2019. Major adverse cardiac events (MACE), defined as the combined endpoint of revascularization, myocardial infarction, and cardiovascular death, were recorded. The participants were categorized according to the stent size: 27 mm for length and 3 mm for diameter. DAPT (aspirin and clopidogrel) was used for at least 2 years for diabetics and 1 year for nondiabetics. The median duration of follow-up was 74.7 months. Results: Out of 1630 participants, 29.0% had diabetes. The diabetics constituted 37.8% of those with MACE. The mean diameter of the stents in the diabetics and nondiabetics was 2.81±0.29 mm and 2.90±0.35 mm, respectively (P>0.05). The mean stent length was 19.48±7.58 mm and 18.92±6.64 mm in the diabetics and nondiabetics, respectively (P>0.05). After adjustments for confounding variables, MACE was not significantly different between the patients with and without diabetes. Although MACE incidence was not affected by stent dimensions in the patients with diabetes, the nondiabetic patients implanted with a stent length exceeding 27 mm experienced MACE less frequently.  Conclusion: Diabetes did not influence MACE in our population. Additionally, stents of different sizes were not associated with MACE in patients with diabetes. We propose that using the DES supplemented by long-term DAPT and tight control of glycemic status after PCI could decrease the adverse consequences of diabetes. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1600 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1600/1031

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 4 2022 10 31 215 222 Fatemeh Rangraz Jeddi Health Information Management Research Centre, Department of Health Information Management & Technology, Kashan University of Medical Sciences, Kashan, Iran Ehsan Nabovati Health Information Management Research Centre, Department of Health Information Management & Technology, Kashan University of Medical Sciences, Kashan, Iran Fateme Peykani Department of Health Information Management & Technology, Kashan University of Medical Sciences, Kashan, Iran Shima Anvari Health Information Management Research Centre, Department of Health Information Management & Technology, Kashan University of Medical Sciences, Kashan, Iran Parissa Bagheri Toolaroud Health Information Management Research Centre, Department of Health Information Management & Technology, Kashan University of Medical Sciences, Kashan, Iran 2022 01 30 2022 07 31 Background: Patients with cardiovascular disorders (CVD) are at higher risk for potential drug-drug interactions (pDDIs) due to complex treatment regimens. This study aimed to evaluate pDDI patterns in physicians’ prescriptions in a specialized heart center using simple software. Methods: This cross-sectional study identified severe and related interactions during a 2-stage survey of experts. The data collected included age, sex, the date of admission and discharge, the length of hospital stay, drug names, inpatient wards, and the final diagnosis. The extracted drug interactions were used as a source of software knowledge. The software was designed using the SQL Server and the C # programming language. Results: Of 24 875 patients included in the study, 14 695 (59.1%) were male. The average age was 62 years. Based on the survey of experts, only 57 pairs of severe pDDIs were identified. The designed software evaluated 185 516 prescriptions. The incidence of pDDIs was 10.5%. The average number of prescriptions per patient was 7.5. The highest frequency of pDDIs was detected in patients with diseases of the lymphatic system (15.0%). Aspirin with heparin (14.3%) and heparin with clopidogrel (11.7%) were the most common documented pDDIs. Conclusion: This study reports the prevalence of pDDIs in a cardiac center. Patients with lymphatic system disorders, male patients, and older patients were at higher risk of pDDIs. This study shows that pDDIs are common among CVD patients and highlights the need to use computer software to screen patients’ prescriptions to assist in detection and prevention. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1611 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1611/1032

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 4 2022 10 31 223 229 Alireza Rostamzadeh Department of Cardiology, Urmia University of Medical Sciences, Urmia, Iran Kamal Khademvatani Department of Cardiology, Urmia University of Medical Sciences, Urmia, Iran Shahyad Salehi Department of Cardiology, Urmia University of Medical Sciences, Urmia, Iran Mirhossein Seyyed-mohammadzad Department of Cardiology, Urmia University of Medical Sciences, Urmia, Iran Mehdi Khani Tabriz University of Medical Sciences, Tabriz, Iran Mojgan Hajahmadipour Rafsanjani Department of Cardiology, Urmia University of Medical Sciences, Urmia, Iran Behnam Askari Department of Cardiology, Urmia University of Medical Sciences, Urmia, Iran Behzad Rahimi Department of Cardiology, Urmia University of Medical Sciences, Urmia, Iran Zahra Mostafavi Department of Cardiology, Urmia University of Medical Sciences, Urmia, Iran Reza Hajizadeh Urmia University of Medical Sciences 2022 06 08 2022 10 29 Target: Bendopnea, defined as dyspnea while bending, can be observed in patients with heart failure (HF). In this study, we investigated the frequency of this symptom in patients with systolic HF and its association with echocardiographic parameters. Material and Methods: In this study, patients with left ventricular ejection fraction (LVEF) ≤45% and decompensated HF referred to our clinics were prospectively recruited. All patients were examined by cardiologists for collecting data on the presence of bendopnea and baseline characteristics. They also underwent electrocardiographic and echocardiographic examinations. All findings compared between patients with or without bendopnea. Results: A total of 120 patients with a mean age of 65.19 ± 12.62 years were evaluated, and 74.8% were men. Bendopnea was observed in 44.2% of the patients. The etiology of HF was ischemic in most patients (81.9%), and the functional class of most patients (85.9%) was III or IV. The mortality rate at 6 months follow-up was comparable between patients with or without bendopnea (6% vs. 9.5%, p=0.507). The waist circumference (odds ratio [OR] 1.037, 95% confidence interval [CI] 1.005 – 1.070, p = 0.023), paroxysmal nocturnal dyspnea (OR 0.338, 95% CI 0.132 – 0.866, p = 0.024), and right atrium size (OR 1.084, 95% CI 1.002 – 1.172, p = 0.044) were associated with bendopnea. Conclusions: Bendopnea can be frequently found among patients with systolic HF. This phenomenon is associated with obesity and baseline symptoms of patients and right atrium size upon echocardiographic examinations. It can help clinicians with the risk stratification of HF patients. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1660 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1660/1033

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 4 2022 10 31 230 235 Parsa Tavassoli Naini School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Marjan Jamalian 2. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. Ali Riahi School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Hamid Reza Roohafza Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. Mohammadreza Shafiei Chaman Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. Mohammad Agharazi School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Masoumeh Sadeghi Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. 2022 07 12 2022 11 27 Background. This study aimed to investigate readmission risk factors after ST-elevation myocardial infarction (STEMI) during a 3-year follow-up. Methods: This study is a secondary analysis of the STEMI Cohort Study (SEMI-CI) in Isfahan, Iran, with 867 patients. A trained nurse gathered the demographic, medical history, laboratory, and clinical data at discharge. Then the patients were followed up annually for 3 years by telephone and invitation for in-person visits with a cardiologist concerning readmission status. Cardiovascular readmission was defined as MI, unstable angina, stent thrombosis, stroke, and heart failure. Adjusted and unadjusted binary logistic regression analyses were applied. Results: Of 773 patients with complete information, 234 patients (30.27%) experienced 3-year readmission. The mean age of the patients was 60.92±12.77 years, and 705 patients (81.3%) were males. The unadjusted results showed that smokers were 21% more likely to be readmitted than nonsmokers (OR, 1.21; P=0.015). Readmitted patients had a 26% lower shock index (OR, 0.26; P=0.047), and ejection fraction had a conservative effect (OR, 0.97; P<0.05). The creatinine level was 68% higher in patients with readmission. An adjusted model based on age and sex showed that the creatinine level (OR, 1.73), the shock index (OR, 0.26), heart failure (OR, 1.78), and ejection fraction (OR, 0.97) were significantly different between the 2 groups. Conclusion: Patients at risk of readmission should be identified and carefully visited by specialists to help improve timely treatment and reduce readmissions. Therefore, it is recommended to pay special attention to factors affecting readmission in the routine visits of STEMI patients. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1677 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1677/1034

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 4 2022 10 31 236 242 Fatih Sivri Department of Cardiology, Hatay Dortyol Hospital, Hatay, Turkey. Hasan Güngör Department of Cardiology, Adnan Menderes University, Aydin, Turkey. Salih Çokpınar Department of Thoracic Surgery, Adnan Menderes Unıversty, Aydin, Turkey. BİRGÜL ANTEPÜZÜMÜ SEZGİN 3Department of Thoracic Surgery, Adnan Menderes Unıversty, Aydin, Turkey. Cemil Zencir Department of Cardiology, Hatay Dortyol Hospital, Hatay, Turkey. 2022 08 07 2022 12 04 Background: The aim of this study was to investigate the association between the platelet/lymphocyte ratio (PLR) and the neutrophil/lymphocyte ratio (NLR) and postoperative atrial fibrillation (POAF) after lung resection. Methods: After the implementation of the exclusion criteria, 170 patients were retrospectively analyzed. PLR and NLR were obtained from fasting complete blood counts before surgery. POAF was diagnosed using standard clinical criteria. The associations between different variables and POAF, NLR, and PLR were calculated using univariate and multivariate analyses. The receiver operating characteristics (ROC) curve was used to determine the sensitivity and specificity of PLR and NLR. Results: Of the 170 patients, 32 with POAF (mean age =71.28±7.27 y, 28 males and 4 females) and 138 patients without POAF (mean age =64.69±10.31 y, 125 males and 13 females) were identified, and the difference in the mean age was statistically significant (P=0.001). It was found that PLR (157.67±65.04 vs 127.52±56.80; P=0.005) and NLR (3.90±1.79 vs 2.04±0.88; P=0.001) were statistically significantly higher in the POAF group. In the multivariate regression analysis, age, lung resection size, chronic obstructive pulmonary disease, NLR, PLR, and pulmonary arterial pressure were independent risk factors. In the ROC analysis, PLR had a sensitivity of 100% and a specificity of 33% (AUC, 0.66; P<0.001), and NLR had a sensitivity of 71.9% and a specificity of 87.7% (AUC, 0.87; P<0.001). A comparison of AUC between PLR and NLR showed that NLR was statistically more significant (P<0.001). Conclusion: This study showed that NLR was a stronger independent risk factor than PLR for the development of POAF after lung resection. https://rhythm.tums.ac.ir/index.php/jthc/article/view/1695 https://rhythm.tums.ac.ir/index.php/jthc/article/download/1695/1035

Tehran University of Medical Sciences The Research in Heart Yield and Translational Medicine (RHYTHM) 3115-7270 17 4 2022 10 31 243 248 Masoumeh Sohrabi Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran. Manoochehr Karami Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Razieh Sadat Mirmoeini Disease Control & Prevention Center, Deputy of Health Services, Hamadan University of Medical Sciences, Hamadan, Iran. Zahra Cheraghi Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran. 2022 08 14 2022 11 26 Background: Uncontrolled hypertension is a major public health problem among patients in developed and developing countries. The present study was conducted to investigate the prevalence and causes of uncontrolled hypertension to facilitate the design of more effective methods of hypertension control. Methods: This cross-sectional study was conducted on 303 adults with hypertension. The Standard Health Literacy Questionnaire was used